Refereed Journal Publications

Biosensors as 21st Century technology for detecting Genetically Modified Organisms in food and feed, Mary Arugula, Yuanyuan Zhang, Aleksandr Simonian, Analytical Chemistry, 2014.

Novel Trends in Affinity Biosensors: Current Challenges and Perspectives, Mary Arugula, Aleksandr Simonian, Measurement Science and Technology, 2013, accepted.

Potential drop based model to analyze electrode passivation by fouling from phenolic compounds, Xiaoyun Yang,Jeffrey Kirsch,Yuanyuan Zhang, Jeffrey Fergus, Aleksandr Simonian, ECS transaction, 2013, Vol.52

Modeling analysis of electrode fouling during electrolysis of phenolic compounds, Xiaoyun Yang,Jeffrey Kirsch,Jeffrey Fergus, Aleksandr Simonian, Electrochimica Acta, 2013, 94, 259~268

Biosensor technology: recent advances in threat agent detection and medicine, Jeffrey Kirsch, Christian Siltanen,Qing Zhou, Alexander Revzin, Aleksandr Simonian, Chemical Society Reviews, 2013, DOI: 10.1039/c3cs60141b

Extended Linear Response for Bioanalytical Applications Using Multiple Enzymes, Vladimir Privman, Oleksandr Zavalov, Aleksandr Simonian, Analytical Chemistry, 2013, 85, 2027~2031

Extended Linear Response for Bioanalytical Applications Using Multiple Enzymes(Support Information), Vladimir Privman, Oleksandr Zavalov, Aleksandr Simonian, Analytical Chemistry, 2013

Design of Biosensors with Extended Linear Response and Binary-Type Sigmoid Output Using Multiple Enzymes Vladimir Privman, Aleksandr Simonian, 2013

Anti-fouling PEDOT: PSS modification on glassy carbon electrodes for continuous monitoring of tricresyl phosphate, Xiaoyun Yang, Jeffrey Kirsch, Eric V.Olsen, Jeffrey W.Fergus, Aleksandr Simonian, Sensors and Actuators, 2013, 177, 659~667

Portable and Remote Electrochemical Sensing System for detection of tricresyl phosphate in gas phase, Xiaoyun Yang, Jeffrey Kirsch, Eric V.Olsen, Jeffrey W.Fergus, Ruel A. Overfelt, Aleksandr L. Simonian, Sensors and Actuators, 2012, 161, 564~569

Affinity and enzyme-based biosensors: recent advances, and emerging applications in cell analysis and point-of-face testing, Ying Liu, Zimple Matharu Michel C. Howland, Alexander Revzin, Aleksandr Simonian, Anal Bioanal Chem, 2012, 404, 1181~1196

Tethered DNA scaffolds on optical sensor platforms for detection of hipO gene from Campylobacter jejuni, Tony J. Gnanaprakasa, Omar A. Oyarzabal, Eric V . Olsen, Valber A. Pedrosa, Aleksandr Simonian Sensors and Actuators, 2011, 156, 304~311

Electrochemical Biosensors for on-chip detection of oxidative stress from immune cells, Jun Yan, Valber A. Pedrosa, James Enomoto, Aleksandr Simonian, Alexander Revzin, Biomicrofluidics 2011, 5,032008

DNA hybridization sensor based on AlGaN-GaN HEMT Siddharth Alur, Resham Thapa, Tony Gnaprakasa, Yaqi Wang, Yogesh Sharma, Edritz Javalosa, Elizabeth Smith, Claude Ahyl, Aleksandr Simonian, Michael Bozack, John Williams, Minseo Park, Current topics in solid state physics, 2011, c, 1~3

Detecting interferon-gamma release from human CD4 T-cells using surface plasmon resonance, Gulnza stybayeva, Markhahat Kairova, Erlan Ramanvulov, Aleksandr Simonian, Alexander Revzin, Colloids and Surfaces, 2010, 80, 251~255

Sensors for Agriculture and the Food Industry, Suiqiong Li, Aleksandr Simonian, Bryan A. Chin, The Electrochemical Society, 2010,

Renewable Nanocomposite Layer-by-Layer Assembled Catalytic Interfaces for Biosensing Applications Saroja Mantha, Valber A. Perdrosa, Eric V. Olsen, Virginia A. Davis, Aleksandr Simonian, Langmuir 2010, 26(24), 19114~19119

Monitoring of diisopropyl fluorophosphate hydrolysis by fluoride-selective polymeric films using absorbance spectroscopy, Madhumati Ramanathan, Lin Wang, James R. Wild, Mark E. Meyeroff, Aleksandr L. Simonian, Analytica Chimica Acta, 2010, 667, 119~122

Micropatterned Nanocomposite Hydrogels for Biosensing Applications, Valber A. Pedrosa, Jun Yan, Aleksandr L. Simonian, Alexander Revzin, Electroanalysis, 2010, 5,1142~1149

Impedance biosensing using phages for bacteria detection: Generation of dual signals as the clue for in-chip assay confirmation M.B. Mejri, H.Baccar, E.Baldrich, F.J. Del Campo, S. Heladi, T.Ktari, A. Simonian, M.Aouni, A.Abdelghani, Biosensors and Bioelectronics, 2010, 26, 1261~1267

Immobilizing Enzymes onto Electrode Arrays by Hydrogel Photolithograohy to Fabricate Multi-Analyte Electrochemical Biosensors Jun Yan, Valber A. Pedrosa, Aleksandr L. Simonian, Alexander Revzin, Applied Materials & Interfaces, 2010, 2 ( 3 ), 748~755

Enzymatic Logic Gates with Nosie-Reducing Sigmoid Response Valber A. Pedrsosa, Dmitriy Melnikov, Marcos Pita, Jan Halamex,Vladimir Privman, Aleksandr Simonian, Evgeny Katz, Int. Journ. of Unconventional Computing, 2010, 6, pp. 451~460

ENZYMATIC LOGIC GATES WITH NOISE-REDUCING SIGMOID RESPONSE Valber A. Pedrsosa, Dmitriy Melnikov, Marcos Pita, Jan Halamex,Vladimir Privman, Aleksandr Simonian, Evgeny Katz, World J. Eng., 2010, 7, p162

Enhanced Stability of Enzyme organophosphate hydrolase interfaced on the carbon nanotubes Valber A. Pedrsosa, Sheetal Paliwal, Shankar Balasubramanian, Dhriti Nepal, Virginia Davis, James Wild, Erlan Ramanculov, Aleksandr Simonian, Colloids and Surfaces, 2010, 77, 69~74

Direct detection of Salmonella typhimurium on fresh produce using phage-based magnetoelastic biosensors Suiqiong Li, Yugui Li, Huiqin Chen, Shi Horikawa, Wen Shen, Aleksandr Simonian,Bryan A. Chin, Biosensors and Bioelectronics, 2010, 26, 1313~1319

Detecting Interferon-Gamma Release from Human CD4 T-cells using surface plasmon resonance Gulnaz Stybayeva, Markhabat Kairova, Erlan Ramanculov, Aleksandr Simonian, Alexander Revzin, Colloids and Surface, 2010, 80, 251~255

Thermal (In)Stability of Type I Collagen Fibrils S.G.Gevorkian, A.E.Allahverdyan, D.S.Gevorgyan, Aleksandr Simonian, Physics review letters, 2009, 102, 048101

Orientation Specific Positioning of Organophosphorus Hydrolase on solid interfaces for biosensor applications Tony E. Reeves, Sheetal Paliwal, Melinda E. Wales, James R.Wild, and Aleksandr L. Simonian, Langmuir, 2009, 25(16), 9615~9618

Enzymatic AND-gate based on electrode-immobilized glucose-6-phosphate dehydrogenase: Towards digital biosensors and biochemical logic systems with low noise , Vladimir Privman, Valber Pedrsosa, Dmitriy Melnikov, Marcos Pita, Aleksandr Simonian, Evgeny Katz, Biosensors and bioelectronics, 2009, 25, 695~701

Electrochemical Properties of Interface Formed by Interlaced Layers of DNA- and Lysozyme-Coated Single-Walled Carbon Nanotubes, Valber A. Pedrsosa, Tony Gnanaprakasa, Shankar Balasubramian, Eric V. Olsen, Virgina A.Davis , Aleksandr Simonian(� - Authors contributed equally in this work). Electrochemistry Communications, 2009, 11, 1401~1404

Lysozyme mediated formation of protein-silica nano-composites for biosensing applications, Madhumati Ramanathan, Heather R. Luckarift, Ainur Sarsenova, James R. Wild, Erlan K. Ramanculov, Eric V. Olsen, Aleksandr L. Simonian, Colloids and Surfaces: Biointerfaces, 2009, 73, 58~64

Copper nanoparticles and carbon nanotubes-based electrochemical sensing system for fast identification of tricresyl-phosphate in aqueous samples and air, Valber Pedrosa, Rigved Epur, Jessica Benton, Ruel A. Overfelt, Aleksandr Simonian, Sensors Actuators B, 2009, 140, 92~97

Strong Antimicrobial Coatings: Single-Walled Carbon Nanotubes Armored with Biopolymers, Dhriti Nepal, Shankar Balasubramanian, Aleksandr Simonian and Virginian Davis, Nano Letters, Vol 8, Issue 7, Pages:1896-1901 (� - Authors contributed equally in this work).

Fluorescence-Based Sensing of P-Nitrophenol and P-Nitrophenyl Substituent Organophosphates, Sheetal  Paliwal; Melinda Wales; Janet Grimsley; James Wild; Alex Simonian. Analytica Chimica Acta, 2007, 596, pp.9-15.

Differential effect of the shape of calcium alginate matrices on the physiology of immobilized neuroblastoma N2a and Vero cells: a comparative study Authors: S. Kintzios, I. Yiakoumetis, G. Moschopoulou, O. Mangana, K. Nomikou, A. Simonian. Biosensors and Bioelectronics, 2007, 23, 543-548

Optical leaky waveguide biosensors for the detection of Organophosphorous pesticides M. Zourob, A. Simonian, J. Wild, S. Mohr, N.  Goddard,The Analyst, 2007, 132, pp.114 - 120.

Development of a Surface Plasmon Resonance Biosensor for the Identification of Campylobacter jejuni, Dong Wei, Omar A. Oyarzabal, Tung-Shi Huang, Shankar Balasubramanian, Srinivas Sista, and Aleksandr L. Simonian, Journal of Microbiological Methods 2007, 69,  78~85.

Highly sensitive phage-based biosensor for the detection of beta-galactosidase, Viswaprakash Nanduri, Shankar Balasubramanian,  Srinivas Sista, Vitaly J. Vodyanoy, Aleksandr L. Simonian Analytica Chimica Acta, .2007,589, 166-172.

Enzyme-Encapsulated Silica Monolayers for Rapid Functionalization of a Gold Surface, H. Luckarift, S. Balasubramanian, S. Paliwal, G. Johnson and A. Simonian, Colloids and Surfaces B: Biointerfaces, 2007, 58, pp.28-33, Invited publication.

Array biosensor based on enzyme kinetics monitoring by fluorescence spectroscopy: Application for neurotoxins detection, M. Ramanathan and A. L. Simonian, Biosensors & Bioelectronics, Biosensors and Bioelectronics, 2007, 22, pp. 3001-3007.

Electrochemical Desorption of Proteins from Gold Electrode Surface, Shankar Balasubramanian, Alexander Revzin, Aleksandr Simonian, Electroanalysis, 2006. Invited publication,  Volume 18, Issue 19-20, pp. 1885-1892.

Lytic Phage as a Specific and Selective probe for detection of Staphylococcus aureus - A Surface Plasmon Resonance Spectroscopic Study, Shankar Balasubramanian; Iryna Sorokulova, Vitaly Vodyanoy, Aleksandr Simonian. Biosensors & Bioelectronics 2007, 22, 948-955.

Phage as a Molecular Recognition Element in Biosensors Immobilized by Physical Adsorption, Viswaprakash Nanduri, Iryna B. Sorokulova, Alexandre Samoylov, Aleksandr Simonian, Valery Petrenko, and Vitaly Vodyanoy, Biosensors & Bioelectronics, 2007, 22, Issue 615 January 2007Pages 986-992.

TCP Electrochemical Detection,� G. Vertelov, W. Gale, and A. Simonian, in: Chemical Sensors and MEMS ECS Transactions, pp. 21-34, 2006


Development of a novel multi-analyte biosensor system for assaying cell division:identification of cell proliferation/death precursor events. S. Kintzios, I. Marinopoulou, G. Moschopoulou, O. Mangana, K. Nomikou, K. Endo, I. Papanastasiou, A. Simonian. Biosensors & Bioelectronics, 2006, 21, pp.1365-1373.

A Fluorescence-based Biosensor for the Detection of Organophosphate Pesticides and Chemical Warfare Agents, L. Viveros,  S. Paliwal, D.A. McCrae, J. Wild, and A. Simonian. Sensors & Actuators B, 2006, 115, p.150-157.

Nanoparticle-based Optical Biosensors for the Direct Detection of Organophosphate Chemical Warfare Agents and Pesticides, A. L. Simonian, T. A. Good, S.-S. Wang, and J. R. Wild. Analytica Chimica Acta, 2005, Vol. 534, Issue 1, pp. 69-77.

Correlation Function and Spectral Density of the Enzymatic Reaction Rate, V. B. Arakelyan, A. L. Simonian, S. Kintzios, A. E. Gevorgyan, T. S. Sukiasyan, A. V. Arakelyan, E. S. Gevorgyan. National Academy of Sciences of RA, Electronic Journal of Natural Sciences, 2(5), 2005, pp. 3-7.


A FET-based Biosensor for The Direct Detection of Organophosphate Neurotoxins, A. L. Simonian, A.W. Flounders, and J. R. Wild. Electroanalysis, 2004, 16,  p.1896-1906.

Study on the mechanism of BERA (Bioelectric Recognition Assay): evidence for immobilized cell membrane interactions with viral fragments, S. Kintzios, F. Bem, O. Mangana, K. Nomikou, P., Markoulatos, N. Alexandropoulos , C. Fasseas, V. Arakelyan, A-L. Petrou, K. Soukouli, G. Moschopoulou, A. Simonian. Biosensors & Bioelectronics, 2004, Volume 20, Issue 4, 1 November 2004, Pages 907-916.

Control of Mammalian Cell and Bacteria Adhesion on Substrates Micropatterned with Poly(ethylene glycol) Hydrogels, Won-Gun Koh, Alexander Revzin, Aleksandr Simonian, Tony Reeves, and Michael Pishko, Biomedical Microdevices, 2003,5:1, 11-19.

Characterization of Oxidoreductase/ Redox Polymer Electrostatic Film Assembly by Surface Plasmon Resonance Spectroscopy, FTIR, and Ellipsometry on Gold, A.L. Simonian, A. Revzin,  J. R. Wild, J. Elkind, and M. V. Pishko, Analytica Chimica Acta, 2002, Vol. 466, 201-212.

Mass Transfer in Amperometric Biosensors Based on Nanocomposite Thin Films of Redox Polymers and Oxidoreductases, Michael V. Pishko, Alexander Revzin, Aleksandr L. Simonian.  Sensors, 2002, 2, 79-90

Glucose, Lactate, and Pyruvate Biosensor Arrays Based on Redox Polymer/Oxidoreductase Nanocomposite Thin Films Deposited on Photolithographically Patterned Gold Microelectrodes, Alexander F. Revzin, Kaushik Sirkar, Aleksandr Simonian, and Michael V. Pishko. Sensors and Actuators, B, 2002, Vol.81, pp.359-368. 

Discriminative Detection of Neurotoxins in Multi-Component Samples, Simonian A. L., Efremenko E. N., and. Wild J. R. Analytica Chimica Acta, 2001, Vol. 444, pp 179-186.

Enzyme-based biosensor for the direct detection of fluorine-containing organophosphates, A.L. Simonian, J.K. Grimsley, A.W. Flounders  J. S. Schoeniger, Tu-Chen Cheng, J.J. DeFrank and J. R. Wild. Analytica Chimica Acta, 2001,  Vol. 442, pp 15-23.

The Influence of External Environment Fluctuations on the Signal Formation of Microbiosensors,  V B. Arakelian, J. R Wild, and A. L. Simonian. Biosensors and Bioelectronics, 2001, Vol.16, #1, pp. 69-72.

Development of Sensors for Direct Detection of Organophosphates; Sol-Gel Modified Field Effect Transistor with Immobilized OPH, A. Flounders, A. Singh, J. Volponi, S. Carichner, K. Wally, A. Simonian, J. Wild, J. Schoeniger, Biosensors and Bioelectronics, 1999, Vol. 14, #8-9 pp, 713-720.

Poly(ethylene glycol) Hydrogel-Encapsulated Fluorophore-Enzyme Conjugates for Direct Detection of Organophosphorus Neurotoxins, R. Russell, M. Pishko, A. Simonian, and J. Wild. Analytical Chemistry, 1999, Vol.71, pp.4909-4912.

An Enzyme Based Biosensor for Direct Determination of  Diisopropyl fluorophosphate, A. L. Simonian,  B. D. DiSioudi, and J. R. Wild,. Analytica Chimica Acta, 1999, Vol. 389, No.1-3, pp. 189-196.

Investigation of Stochastic Fluctuations in the Signal Formation of Microbiosensors, V B. Arakelian, J. R Wild, and A. L. Simonian. Biosensors and Bioelectronics, 1998, Vol. 13, No.1, 55-59.

New Concept for Discriminative Biosensor: Detection of Organophosphates in the Presence of Other Cholinesterases Inhibitors, A. L. Simonian, E. I. Rainina, and J. R Wild. Analytical Letters, 1997, 30(14), 2453-2468.

A Tryptophan-2-monooxygenase Based Amperometric Biosensor for L-tryptophan Determination. Use of a Competitive Inhibitor as a Tool for Selectivity Increase, A. L. Simonian, E. I. Rainina, P. F. Fitzpatrick, and J. R Wild. Biosensors and Bioelectronics, 1997, Vol. 12, No.5 pp.363-371.

The Development of a New Biosensor Based on Recombinant E.coli for the Detection of Organophosphorus Neurotoxins, E.Rainina , A.Simonian, A.Efremenco, S.Varfolomeyev and J.Wild , Biosensors and Bioelectronics, 1996. Vol. 11, No 10, pp. 991-1000.

Cell Biosensor for Assay Phenol in Aqueous Solutions, E.I.Rainina, I.E.Badalian, O.V.Ignatov, A.S.Fedorov, A. L. Simonian. Applied Biochemistry and Biotechnology, 1996. V. 55, No 1. 117-127.

A Biosensor for L-Tryptophan Determination Based on Recombinant Pseudomonas savastanoi Tryptophan-2-Monooxygenase, A. L. Simonian, E. I. Rainina, J. R Wild, P. F. Fitzpatrick. Analytical Letters, 1995, Vol. 28, No. 10, pp. 1751 - 1761.

Flow-Injection Amperometric Biosensor Based on Immobilized L-Lysineoxidase for L-Lysine determination, A. L. Simonian, I. E.Badalian, T. T.Berezov, I. P.Smirnova, S. H.Khaduev. Analytical Letters, 1994, V.27(15), pp. 2849 - 2860.

L-Lysine-2-monooxygenase Production by Some Strains of Pseudomonas Fluorescens and Pseudomonas Putida Species, G. E.Khachatrian, A. L. Simonian. World Journal of Microbiology&Biotechnology. 1994. V.10, No. 6, pp. 711-712.

A Biosensor for L-Proline Determination by Use of Immobilized Microbial Cells, A.L.Simonian, I.E.Badalian, G.E.Khachatrian, S.Sh.Tatikian, E.I.Rainina, T.A.Makhlis, V.I.Lozinsky, S.D.Varfolomeyev. Applied Biochemistry and Biotechnology, 1992. Vol. 36, pp. 199-210.

A Flow-Through Enzyme Analyzer for Determination of L-Lysine Concentration, Biosensors and Bioelectronics, 1991. A. L. Simonian, G.E.Khachatrian, S.Sh.Tatikian, Ts.M.Avakian, I.E.Badalian. Vol.6, No. 2, pp. 93-99.

Kinetic Properties of Bacterial Urate Oxidase Entrapped in Hydrated Reversed Micelles, E.A.Malakhova, N.A.Chebotareva, B.I.Kurganov, A. L. Simonian. Biological Membranes (Russian). 1991. Vol.8, No.5, pp.453-459.

Incorporation of Water-Soluble Enzymes Glucoseoxidase and Urate Oxidase Into Lecithin  Liposomes, T.G.Ambartzumyan, S.Ja.Adamian, L.S.Petrosian, A. L. Simonian. Biological Membranes (Russian). 1991. Vol.8, No.12, pp.1254-1259.

Kinetic Properties and Termoinactivation of Bacterial Uricas, A. L. Simonian, S.Sh.Tatikian, J.J.Kulys. Biochemistry  (Russian). 1985. Vol. 50, No. 5, pp.782-785.

Determination of Uric Acid in Biological Solution Using Bienzyme Electrode, J.J.Kulys, M.V.Pesliakene, V.A.Laurinavicus, S.Sh.Tatikian, A. L. Simonian. Journal of Analytical Chemistry (Russian). 1985. Vol.XL, No 11, pp.2077-2080

Application of immobilized glucose oxidase and urat oxidase in analytical systems, A. L. Simonian, S.Sh.Tatikian, G. Khachatryan. Applied Biochemistry and Microbiology (Russian), 1986, Vol. 12 (6) pp. 675-679.