39. Chattopadhyay, Pratibhash; Gupta, Ram B. Supercritical CO2 Based Production of Magnetically Responsive Micro- And Nanoparticles For Drug Targeting., Ind. Eng. Chem. Res., (2002), 41(24), 6049-6058.
Magnetically responsive, controlled-release drug
formulations are needed for targeted drug delivery, esp. for toxic drugs. A supercrit. antisolvent (SAS) technique is used to produce magnetically
responsive poly(Me methacrylate), 50/50 poly(DL-lactide-co-glycolide), and Eudragit
RS polymer particles via copptn. of the polymer with a
suspension of magnetite particles in mineral oil and a fatty acid surfactant,
by using dichloromethane as the solvent.
The SAS technique is again used to ppt. drug-loaded magnetically
responsive polymer particles. A
modification of the SAS process, the SAS-EM (enhanced mass transfer) technique