34. Chattopadhyay, P.; Gupta, R. B.  Production of griseofulvin nanoparticles using supercritical CO2 antisolvent with enhanced mass transfer.    Int. J. Pharm.  (2001), 228(1-2),  19-31.


Griseofulvin (GF) is a poor water sol., antifungal agent.  The bioavailability of the drug and its absorption from the gastrointestinal tract can be greatly improved by particle size redn.  In this work, supercrit. antisolvent pptn. with enhanced mass transfer (SAS-EM) has been proposed for the prodn. of GF nanoparticles.  SAS-EM is a modification of the currently existing supercrit. antisolvent (SAS) pptn. technique and also utilizes supercrit. CO2 as the antisolvent.  In SAS-EM however, the soln. jet is deflected by a surface vibrating at an ultrasonic frequency that atomizes the jet into small micro droplets.  Further, the ultrasound field generated by the vibrating surface inside the supercrit. media enhances mass transfer and prevents agglomeration due to increased mixing.  GF nanoparticles of different sizes and morphologies have been obtained by varying the vibration intensity of the deflecting surface, which in turn is adjusted by changing the power supply to the attached ultrasound transducer.  GF nanoparticles as low as 130 nm in size have been obtained corresponding to a power supply of 180 W.  The effect of using different solvents on the size and morphol. of the particles has also been studied. 


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