28. Kumar, Rajesh; Gupta, Ram B.; Betageri, Guru V.  Formulation, characterization, and in vitro release of glyburide from proliposomal beads.    Drug Delivery  (2001),  8(1),  25-27.


The objective of our study was to formulate and evaluate proliposomes in the form of enteric-coated beads using glyburide as a model drug.  The beads were enteric coated with Eudragit L-100 by a fluidized bed coating process using tri-Et citrate as plasticizer.  Content uniformity of glyburide was estd. using HPLC anal. of beads dissolved in methanol.  These proliposomal beads formed liposomes on disintegration in phosphate buffered saline (pH 7.4), which was confirmed by TEM.  The dissoln. study of enteric-coated beads exhibited enhanced dissoln. compared with pure drug and a com. product.  Liposomes can be successfully prepd. for oral administration in the form of enteric-coated beads that may offer a stable system to produce liposomes for oral administration.


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